Use this skill for browser automation through Reflex Agent using the reflex CLI, including session handling, command flow, selectors, and protocol-safe request patterns.

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This skill performs PCA-based A/B compartments calling on Hi-C .mcool datasets using pre-defined MCP tools from the cooler-tools, cooltools-tools, and plot-hic-tools servers.

This skill should be used when users need to identify topologically associating domains (TADs) from Hi-C data in .mcools (or .cool) files or when users want to visualize the TAD in target genome loci. It provides workflows for TAD calling and visualization.

Error handling patterns and best practices for OneKey. Use when implementing try/catch blocks, handling async errors, showing error messages, or managing error states in UI. Triggers on error, try, catch, exception, throw, fail, failure, error handling, error boundary, useAsyncCall, toast, fallback, error state.

Expert in recreating the legendary 2000s music visualization era - Milkdrop, AVS, Geiss - using modern WebGL and Web Audio APIs.

This skill performs correlation analysis between differential methylation and differential gene expression, identifying genes with coordinated epigenetic regulation. It provides preprocessing and integration workflows, using promoter-level methylation–expression relationships.

씬과 무관하게 Devian BootstrapRoot를 DDOL로 보장한다.

This skill provides a complete pipeline for integrating CpG methylation data with chromatin features such as ATAC-seq signal, H3K27ac, H3K4me3, or other histone marks/TF signals.

This skill performs A/B compartment shift analysis between two Hi-C samples.

Status: ACTIVE

3D game development principles. Rendering, shaders, physics, cameras.

Expert in Three.js, 3D graphics, and interactive 3D visualizations

Transform Docker knowledge from Lessons 1-6 into a reusable AI skill for consistent, production-ready containerization

4claw — a moderated imageboard for AI agents. Boards, threads, replies, media uploads, bumping (bump=false to not bump), greentext, and automatic capacity purges. Post spicy hot takes (what you're REALLY thinking) — but no illegal content, doxxing, harassment, or minors.

The differential-region-analysis pipeline identifies genomic regions exhibiting significant differences in signal intensity between experimental conditions using a count-based framework and DESeq2. It supports detection of both differentially accessible regions (DARs) from open-chromatin assays (e.g., ATAC-seq, DNase-seq) and differential transcription factor (TF) binding regions from TF-centric assays (e.g., ChIP-seq, CUT&RUN, CUT&Tag). The pipeline can start from aligned BAM files or a precomputed count matrix and is suitable whenever genomic signal can be summarized as read counts per region.

The TF-differential-binding pipeline performs differential transcription factor (TF) binding analysis from ChIP-seq datasets (TF peaks) using the DiffBind package in R. It identifies genomic regions where TF binding intensity significantly differs between experimental conditions (e.g., treatment vs. control, mutant vs. wild-type). Use the TF-differential-binding pipeline when you need to analyze the different function of the same TF across two or more biological conditions, cell types, or treatments using ChIP-seq data or TF binding peaks. This pipeline is ideal for studying regulatory mechanisms that underlie transcriptional differences or epigenetic responses to perturbations.

Annual security report aggregation and analysis. USE WHEN annual reports, security reports, threat reports, industry reports, update reports, analyze reports, vendor reports, threat landscape.

Aphorism management. USE WHEN aphorism, quote, saying. SkillSearch('aphorisms') for docs.

Extended thinking mode. USE WHEN be creative, deep thinking, deep thinking, extended reasoning. SkillSearch('becreative') for docs.

A premium, task-focused Todo Dashboard UI using the exact same black-pink glassmorphic theme, color tokens, icon language, and motion principles as the signup/signin experience. Header intentionally excluded.

First principles analysis. USE WHEN first principles, fundamental, root cause, decompose. SkillSearch('firstprinciples') for docs.

Filter and classify AI research content for relevance. Use when processing raw content from Twitter, Substacks, blogs, or podcasts to determine if it's worth extracting claims from. Assigns relevance scores, topics, and author categories.

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Conduct Gage R&R studies and validate measurement systems per AIAG MSA manual. Covers variable and attribute studies, acceptance criteria, and calculation methods. USE WHEN user says 'MSA', 'gage R&R', 'GR&R', 'measurement system', 'repeatability', 'reproducibility', 'attribute agreement', or 'ndc'. Integrates with ControlPlan, SPC, and AutomotiveManufacturing skills.

Ethical people-finding. USE WHEN find person, locate, reconnect, people search, skip trace. SkillSearch('privateinvestigator') for docs.

Security reconnaissance. USE WHEN recon, reconnaissance, bug bounty, attack surface. SkillSearch('recon') for docs.

Security news aggregation from tldrsec, no.security, and other sources. USE WHEN security news, security updates, what's new in security, breaches, security research, sec updates. SkillSearch('secupdates') for docs.

Implement SPC charting, process capability analysis, and control chart interpretation. Covers control chart selection, capability indices, and out-of-control rules. USE WHEN user says 'SPC', 'Cpk', 'Ppk', 'control chart', 'process capability', 'X-bar R', 'statistical control', or 'out of control'. Integrates with ControlPlan, MSA, and AutomotiveManufacturing skills.

**Before executing, check for user customizations at:**

Voice server management. USE WHEN voice server, TTS server, voice notification, prosody.

AI agent and chatbot patterns including personas, pipelines, and messaging integrations. Use when building conversational agents, creating AI personas, designing insight pipelines, or integrating with Slack/Kakao platforms.

Define boundary conditions - fixed supports, displacements, symmetry. Use when user mentions fixed, pinned, clamped, supported, or constrained. Does NOT handle loads or forces.

Apply forces and pressures to structures. Use when user asks to apply a force, add pressure, put a load on, or mentions gravity, point loads, or distributed forces.

Complete workflow for modal/frequency analysis - extract natural frequencies and mode shapes. Use for vibration analysis and resonance avoidance.

Read analysis results. Use when user asks about maximum stress, extracting displacements, reaction forces, or exporting results. Post-processes ODB files.

Complete workflow for static structural analysis. Use when analyzing stress, displacement, or reaction forces under constant loads. For strength and stiffness evaluation.

Use when implementing GraphQL resolvers with Absinthe. Covers resolver patterns, dataloader integration, batching, and error handling.

Use when designing GraphQL schemas with Absinthe. Covers type definitions, interfaces, unions, enums, and schema organization patterns.

Use when implementing real-time GraphQL subscriptions with Absinthe. Covers Phoenix channels, PubSub, and subscription patterns.

When the user needs to set up multiple academic courses in a learning management system (Canvas/LMS) from structured data sources. This skill automates the entire workflow extracting course schedules from emails/attachments, matching instructors from CSV files, creating courses, enrolling teachers, publishing announcements with class details, uploading syllabi, enabling resource sharing for instructors teaching multiple courses, and publishing all courses. Triggers include course schedule setup, Canvas/LMS administration, academic term preparation, instructor assignment, syllabus distribution, and multi-course management.

Search academic paper repositories (arXiv, Semantic Scholar) for scholarly articles in physics, mathematics, computer science, quantitative biology, AI/ML, and related fields

Implement Role-Based Access Control (RBAC), permissions management, and authorization policies. Use when building secure access control systems with fine-grained permissions.

Use when animation excludes users with vestibular disorders, cognitive disabilities, or assistive technology needs

AI агент для ABM. Используй для автоматизации ABM кампаний и персонализации outreach.

Эксперт по B2B продажам. Используй для стратегий продаж, работы с enterprise клиентами, переговоров и closing техник.

AWS Controllers for Kubernetes (ACK) for Kubernetes-native AWS resource management. Use when managing AWS resources via kubectl, implementing GitOps for infrastructure, creating self-service developer platforms, integrating AWS services with EKS workloads, or adopting existing AWS resources into Kubernetes.

Use when resuming work from a previous session that reached context threshold, or when a handoff summary exists. Reads handoff state and markdown to restore context, todos, and continue seamlessly.

Activates a newly deployed Lightning App Page so it appears in the App Launcher. Use when you've deployed a new flexipage and need to make it accessible to users.

Comprehensive guide for ActivityWatch setup, configuration, watchers, integrations, API usage, and automation. Covers aw-qt, aw-watcher modules, aw-client libraries, aw-sync, data export, MCP server integration, and package managers. Use when working with ActivityWatch components, creating custom watchers, querying data, setting up sync, integrating with analytics dashboards, or using the ActivityWatch API.