Access US Patent and Trademark Office (USPTO) patent data via the PatentsView REST API and Google Patents Public Data (BigQuery). Use it to search patents by inventor, assignee, CPC classification, or keywords; download full patent metadata and claims; analyze patent portfolios; and track technology trends. Ideal for IP landscape analysis, competitor monitoring, prior art searches, and technology forecasting in life sciences and biotech.

Guide for designing and creating scientific schematics, diagrams, and graphical abstracts. Covers tool selection (BioRender, Inkscape, Affinity Designer, PowerPoint), design principles for biological pathway diagrams, molecular mechanism schematics, experimental workflow diagrams, and graphical abstracts for journal submissions. Includes composition rules, icon sourcing, color usage for biological entities, and accessibility considerations. Use when planning or creating a scientific figure that is primarily illustrative rather than data-driven.

Create effective scientific presentations for conferences, seminars, thesis defenses, and grant pitches. Slide design principles, talk structure, timing, data visualization for slides, quality assurance. Works with PowerPoint and LaTeX Beamer. For poster creation use latex-research-posters.

DiffDock is a diffusion-based molecular docking tool that predicts protein-ligand binding poses without requiring a predefined binding site. Use it when the binding site is unknown, when traditional docking fails, or when exploring multiple binding modes. Pipeline: prepare protein (PDB) and ligand (SMILES/SDF) inputs → run DiffDock inference → analyze confidence-ranked poses → visualize in PyMOL or NGLview.

Search and retrieve cryo-EM density maps, fitted atomic models, and metadata from the Electron Microscopy Data Bank (EMDB) REST API. Query by keyword, resolution, method, or organism; fetch entry details, map download URLs, associated PDB models, and publications. No authentication required. For experimental atomic coordinates use pdb-database; for AlphaFold predicted structures use alphafold-database-access.

Python library for analyzing molecular dynamics (MD) trajectories from GROMACS, AMBER, NAMD, CHARMM, and LAMMPS. Reads topology and trajectory files into Universe objects; supports RMSD, RMSF, radius of gyration, contact maps, hydrogen bond analysis, PCA, and custom distance/angle calculations across millions of frames. Use for structural analysis after MD simulations; use OpenMM or GROMACS directly for running simulations.

Molecular featurization hub (100+ featurizers) for ML. Convert SMILES to numerical representations via fingerprints (ECFP, MACCS, MAP4), descriptors (RDKit 2D, Mordred), pretrained models (ChemBERTa, GIN, Graphormer), and pharmacophore features. Scikit-learn compatible transformers with parallelization, caching, and state persistence. For QSAR, virtual screening, similarity search, and deep learning on molecules.

Query Open Targets Platform GraphQL API for target-disease associations, evidence scores, drug-target links, and safety data. Search targets by gene symbol, diseases by EFO ID, retrieve evidence scores from 20+ data sources, drug mechanisms, and tractability assessments. For ChEMBL bioactivity use chembl-database-bioactivity; for clinical trials use clinicaltrials-database-search.

Query RCSB PDB (200K+ experimental structures) via rcsb-api Python SDK. Text, attribute, sequence, and structure similarity search. Fetch metadata via Schema or GraphQL. Download PDB/mmCIF coordinate files. For AlphaFold predicted structures use alphafold-database-access.

Rowan is a cloud-based computational chemistry platform providing quantum chemistry calculations via a Python SDK. Use it to run geometry optimization, conformer generation, torsional scans, and energy minimization with DFT or semiempirical methods, and retrieve molecular properties (dipole moment, partial charges, frontier orbital energies) — without managing local quantum chemistry software or HPC clusters.

Query ZINC15/ZINC22 virtual compound libraries for drug discovery. Search purchasable lead-like, fragment-like, and drug-like compounds by molecular weight, logP, reactivity class, or SMILES similarity. Download 3D compound sets for docking, retrieve SMILES for in-silico screening. ZINC20 contains 1.4B compounds; purchasable subset is 750M. For bioactivity data use chembl-database-bioactivity; for approved drugs use drugbank-database-access.

Infer, analyze, and visualize intercellular communication from scRNA-seq data using CellChat (R). Pipeline: create CellChat object from Seurat or count matrix → subset CellChatDB ligand-receptor database → identify over-expressed genes per cell group → infer communication probabilities → compute pathway-level signaling → analyze network centrality (senders, receivers, influencers) → visualize with chord diagrams, heatmaps, and bubble plots → compare across conditions. Human and mouse supported. Use liana for a pure-Python equivalent.

Constraint-based reconstruction and analysis (COBRA) of genome-scale metabolic models. FBA, FVA, gene/reaction knockouts, flux sampling, production envelopes, gapfilling, and media optimization. Use for metabolic engineering strain design, essential gene identification, and flux distribution analysis. For kinetic modeling use tellurium; for pathway visualization use Escher.

Product photography for Etsy — composition, lighting, backgrounds, editing, lifestyle shots, 360 views

Etsy pricing — cost calculation, competitor pricing, perceived value, shipping cost integration, sales and coupons

Shop branding — banner design, logo, brand story, cohesive listing photography, packaging

DIY product photography — setup, lighting, backgrounds, editing, lifestyle shots, 360 views

Self-contained design transformer — invoke directly, do not decompose. Transforms a design reference HTML file into a Vibes app. Use when user provides a design.html, mockup, or static prototype to match exactly.

Self-contained SaaS pipeline — invoke directly, do not decompose.

Coordinates album release including QA, distribution prep, and platform uploads. Use when mastering and album art are complete and the user is ready to release.

Runs the session startup procedure - verifies setup, loads config and state, checks skill models, and reports project status. Use at the beginning of a fresh session.

Validates album directory structure, file locations, and content integrity. Use before release or whenever the user wants to check an album's structural health.

Select the right Python charting library (seaborn, matplotlib, graphviz) and produce publication-quality static visualizations. Use when creating charts, plots, graphs, diagrams, heatmaps, visualizations from data, or when choosing between matplotlib/seaborn/graphviz. Also triggers for network diagrams, flowcharts, dependency trees, state machines, and entity-relationship diagrams. For interactive browser-rendered charts or uploaded data exploration, defer to charting-vega-lite instead.

Lightweight DAG workflow runner with checkpoint resume and detachable tasks. Use when orchestrating 3+ sequential or parallel tool calls into a single invocation, or when pipelines need resume-from-failure without re-running succeeded steps.

Convert raster images (photos, paintings, illustrations, line art) into SVG vector reproductions. Use when the user uploads an image and asks to reproduce, vectorize, trace, or convert it to SVG. Also use when asked to decompose an image into shapes, create an SVG version of a picture, or faithfully reproduce artwork as vector graphics. Handles graphic/line-art inputs (Kandinsky, architectural drawings, ink work) via a compositional pipeline that extracts lines as SVG strokes. Do NOT use for creating original SVG illustrations from text descriptions — only for converting existing raster images.

Selective simplification: one pipeline pass at high K → zone-aware contour

File-upload bridge for Claude Code on the Web. CCotw has no native file mount; this skill creates a throwaway GitHub branch the user can drop files onto via the github.com web UI, then fetches them locally on the next turn. Use when the user wants to upload, share, or send files into the session, or when a task clearly needs files the user has on disk that aren't in the repo.

Browser automation via webctl CLI in Claude.ai containers with authenticated proxy support. Use when users mention webctl, browser automation, Playwright browsing, web scraping, or headless Chrome in container environments.

Build RAG systems for construction knowledge bases. Create searchable AI-powered construction document systems

Build KPI dashboards for construction projects. Track CPI, SPI, quality, safety metrics in real-time.

Automate construction data workflows. Build ETL pipelines and DAG workflows for recurring tasks.

Build n8n pipeline for automated cost estimation from Revit/IFC using DDC CWICR database and LLM classification.

Automate construction photo report generation using n8n with AI-powered image analysis.

Create n8n workflow for daily task assignment from PTO engineer to foreman via Telegram bot with status reporting.

Build Telegram bots for construction field workers. Real-time reporting, photo uploads, task assignments, progress tracking. Integrate with n8n for automated workflows.

Comprehensive verification system for construction automation deliverables. Use after completing estimates, schedules, reports, or data processing tasks to ensure quality.

IoT-based material tracking for construction sites. Monitor material delivery, storage conditions, usage, and inventory with sensors, RFID, GPS, and real-time dashboards.

Build no-code/low-code automation workflows for construction using n8n. Automate data extraction, cost estimation, report generation, and system integrations without writing code.

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