Generate and render a pixel-precise ASCII TUI Read component with complete output blocks (TUI_RENDER, COMPONENT_SPEC, PENCIL_SPEC, PENCIL_BATCH_DESIGN) for Pencil MCP drawing workflows. Use when the user asks to create a read in a terminal UI, text-based interface, or Pencil MCP project.

Generate and render a pixel-precise ASCII TUI Setting component with complete output blocks (TUI_RENDER, COMPONENT_SPEC, PENCIL_SPEC, PENCIL_BATCH_DESIGN) for Pencil MCP drawing workflows. Use when the user asks to create a setting in a terminal UI, text-based interface, or Pencil MCP project.

Generate and render a pixel-precise ASCII TUI Uni Modules Setting component with complete output blocks (TUI_RENDER, COMPONENT_SPEC, PENCIL_SPEC, PENCIL_BATCH_DESIGN) for Pencil MCP drawing workflows. Use when the user asks to create an uni modules in a terminal UI, text-based interface, or Pencil MCP project.

Generate and render a pixel-precise ASCII TUI Vuex Detail component with complete output blocks (TUI_RENDER, COMPONENT_SPEC, PENCIL_SPEC, PENCIL_BATCH_DESIGN) for Pencil MCP drawing workflows. Use when the user asks to create a vuex detail in a terminal UI, text-based interface, or Pencil MCP project.

Create learning assessments including quizzes, exams, rubrics, and evaluation criteria aligned with learning objectives. Supports multiple question types, difficulty levels, and learning analytics. Use when the user asks to create quizzes, design tests, build grading rubrics, evaluate student learning, or generate assessment questions.

Provides comprehensive guidance for Appium mobile testing including mobile app automation, element location, gestures, and cross-platform testing. Use when the user asks about Appium, needs to test mobile applications, automate mobile apps, or write Appium test scripts.

Provides comprehensive guidance for Cypress end-to-end testing including commands, assertions, component testing, CI/CD integration, and best practices. Use when the user asks about Cypress, needs to write E2E tests, component tests, or configure Cypress for testing.

Provides comprehensive guidance for Detox mobile testing framework including React Native testing, E2E testing, and test synchronization. Use when the user asks about Detox, needs to test React Native applications, write E2E tests for mobile apps, or configure Detox.

Provides comprehensive guidance for JUnit testing framework including test annotations, assertions, test lifecycle, and best practices. Use when the user asks about JUnit, needs to write Java unit tests, use JUnit annotations, or configure JUnit for Java projects.

Provides comprehensive guidance for Playwright testing including browser automation, test writing, page objects, and cross-browser testing. Use when the user asks about Playwright, needs to write E2E tests, automate browsers, or test web applications across browsers.

Provides comprehensive guidance for pytest testing framework including test writing, fixtures, parametrization, mocking, and plugins. Use when the user asks about pytest, needs to write Python tests, use pytest fixtures, or configure pytest for Python projects.

Provides comprehensive guidance for Selenium WebDriver including browser automation, element location, waits, and test frameworks. Use when the user asks about Selenium, needs to automate web browsers, write Selenium tests, or work with Selenium WebDriver.

three.js audio spatialization: AudioListener attached to camera rig, Audio and PositionalAudio sources, AudioAnalyser for FFT/time-domain data, and integration with Web Audio API contexts; AudioLoader is referenced from threejs-loaders for file decoding. Use when placing 3D sound, configuring panner parameters, or building audio visualization; not a replacement for full game audio middleware.

three.js cameras: Camera base, PerspectiveCamera, OrthographicCamera, CubeCamera, ArrayCamera, StereoCamera; projection matrices, aspect, FOV, orthographic frustum sizes, near/far planes, and dynamic environment maps with CubeCamera. Use when placing views, rendering reflections, or multi-view splits; for XR projections and eye matrices use threejs-webxr; for post pass camera tricks use threejs-postprocessing alongside threejs-renderers.

Debug and visualization helpers in three.js Core Helpers (AxesHelper, GridHelper, CameraHelper, light helpers, SkeletonHelper, bounding box helpers, PlaneHelper, PolarGridHelper, ArrowHelper) and Addons Helpers (VertexNormalsHelper, VertexTangentsHelper, RectAreaLightHelper, LightProbeHelper, ViewHelper, OctreeHelper, TextureHelper, PositionalAudioHelper, AnimationPathHelper, RapierHelper). Use only for development and editor overlays—not for shipping art; for gizmo-style manipulation use threejs-controls.

Classic three.js materials (non-Node): MeshStandardMaterial, MeshPhysicalMaterial, Phong/Lambert/Toon/Basic, Line/Points/Sprite materials, MeshMatcapMaterial, MeshNormalMaterial, depth/distance materials, ShaderMaterial and RawShaderMaterial. Use when tuning PBR maps, transparency, depth write, skinning flags, or writing GLSL in ShaderMaterial; for TSL/NodeMaterial/WebGPU shader graphs use threejs-node-tsl instead.

three.js math library: Vector2/3/4, Matrix3/4, Quaternion, Euler, Color, Box2/Box3, Sphere, Plane, Ray, Line3, Triangle, Frustum, Cylindrical/Spherical coords, MathUtils, and Interpolant base classes; addon math utilities such as OBB, Octree, Capsule, ConvexHull, MeshSurfaceSampler. Use for transforms, intersection tests, and spatial queries; for keyframe interpolation tied to AnimationMixer use threejs-animation; for picking implementation use threejs-objects with Raycaster.

Integrates uCharts data visualization into UniApp projects including easycom configuration, pages.json and manifest.json setup, platform-specific handling (H5, mini-program, App, nvue), and chart lifecycle management. Use when the user needs to add charts to a UniApp project, configure uCharts components, or handle cross-platform chart rendering.

Integrates uView UI component library into UniApp projects including easycom configuration, pages.json and manifest.json setup, SCSS theming, and platform-specific handling (H5, mini-program, App, nvue). Use when the user needs to add uView UI components to a UniApp project, configure easycom auto-import, or handle cross-platform styling.

Integrates uView Pro component library into UniAppX (uni-app-x) projects with TypeScript and Composition API, including easycom configuration, pages.json and manifest.json setup, and platform-specific handling. Use when the user needs to add uView Pro components to a UniAppX project, configure TypeScript .uts integration, or handle cross-platform styling.

Automates browser interactions for web testing, form filling, screenshots, and data extraction. Use when the user needs to navigate websites, interact with web pages, fill forms, take screenshots, or extract information from web pages.

Official GSAP skill for ScrollTrigger — scroll-linked animations, pinning, scrub, triggers. Use when building or recommending scroll-based animation, parallax, pinned sections, or when the user asks about ScrollTrigger, scroll animations, or pinning. Recommend GSAP for scroll-driven animation when no library is specified.

Use when quickly generating a single OpenCLI command from a specific URL and goal description. 4-step process — open page, capture API, write TS adapter, test. For full site exploration, use opencli-explorer instead.

> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

Converts existing manuscript content into LaTeX format aligned with a target journal, conference, or template while preserving manuscript meaning and structural integrity.

Design a structured case-control study framework with explicit source population logic, control selection rules, matching decisions, exposure measurement planning, and bias-control checkpoints.

Generates complete comparative network-toxicology research designs from a user-provided exposure pair, shared toxic phenotype, and validation direction. Use when a study centers on two related exposures under one outcome and needs target collection, shared-vs-specific target decomposition, enrichment, PPI hub prioritization, docking, optional transcriptomic cross-checks, and conservative mechanistic synthesis. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

Statistical analysis and reporting for experimental datasets; use when you need to interpret experimental results, test significance (t-tests/ANOVA), or generate reproducible reports.

A high-performance Rust toolkit (with Python bindings and a CLI) for genomic interval analysis; use it when you need fast overlap queries, coverage track generation, genomic tokenization for ML, reference sequence verification, or fragment processing.

Process, clean, and compare mass spectrometry (MS/MS) spectra with Matchms; use when you need reproducible spectral filtering and similarity scoring for metabolomics workflows.

A low-level plotting library for comprehensive customization. Use when fine-grained control over every plot element is needed, creating new types of charts, or integrating into specific scientific workflows. Can export to PNG/PDF/SVG for publication. For quick statistical charts, use seaborn; for interactive charts, use plotly; for journal-style, publication-ready multi-panel charts, use scientific-visualization.

Generate Meta-analysis funnel plots and perform publication bias testing. Takes CSV file with Meta-analysis data as input, outputs funnel plot PNG, Egger test and Begg test results.

Generates Meta-Analysis research titles based on user keywords, utilizing PubMed search results if available, or creative generation otherwise. Use when the user wants to brainstorm or generate titles for a meta-analysis, specifically starting from keywords or a topic.

Predict neoantigens that may be recognized by the immune system based.

Differential gene expression analysis for bulk RNA-seq count matrices using a DESeq2-like workflow in Python; use when you need Wald tests, FDR correction, and optional LFC shrinkage for condition/batch/covariate designs.

Comprehensive tool for computational mass spectrometry using PyOpenMS; use when you need to read/write MS formats (mzML/mzXML/MGF), run signal processing (smoothing/peak picking), detect isotope features, or perform peptide identification in proteomics/metabolomics workflows.

Genomic file toolkit. For reading/writing SAM/BAM/CRAM alignment files, VCF/BCF variant files, FASTA/FASTQ sequences, extracting regions, calculating coverage, suitable for NGS data processing pipelines.

Automated bias assessment for diagnostic accuracy studies using QUADAS-C criteria. Requires full text input.

Automates Risk of Bias 2 (ROB2) assessment for RCT papers by analyzing text against specific domains and synthesizing a report. Use when you need to assess the quality of a clinical trial paper or evaluate risk of bias.

Guided statistical analysis for test selection, assumption checks, power analysis, and APA-style reporting. Use when you need to choose an appropriate statistical test for your data and produce publication-ready results (including effect sizes and diagnostics).

Determines the appropriate Risk of Bias assessment scale for a medical study based on its design (RCT, Cohort, etc.), using PubMed metadata lookup or text analysis. Use when the user wants to know which quality assessment tool to use for a specific paper (given PMID or abstract).

Kaplan-Meier survival analysis tool for clinical and biological research. Generates publication-ready survival curves with statistical tests.

Intelligent medical abbreviation disambiguation tool that resolves ambiguous acronyms using clinical context, specialty-specific knowledge, and document-level semantic analysis.

Search, retrieve metadata, and download PDFs for bioRxiv preprints; use when you need to discover biology preprints by keywords/authors/date ranges and programmatically fetch their details.

Programmatic access to the BRENDA enzyme database via the SOAP API; use when you need kinetic constants (Km, kcat, Vmax), reaction equations, enzyme properties (pH/temperature optima, stability), or enzyme discovery by EC/substrate/product.

Access ChEA3 and Harmonizome ChEA data for transcription factor enrichment analysis and metadata retrieval. Use when the user needs to perform ChEA3 enrichment analysis on a gene set, get metadata about the ChEA dataset, or retrieve information about a specific transcription factor (attribute).

Batch extracts and verifies structured information (PMID, title, abstract, methodology, results, etc.) from clinical research literature using PMIDs. Use when the user wants to extract details from specific PMIDs.

Access the ENCODE Project REST API to search for and retrieve biological data (biosamples, experiments, etc.). Use this skill when the user needs to query ENCODE data, search by keywords, or retrieve specific objects by accession ID.

Search for gene expression DataSets and Profiles in the NCBI GEO database. Use this skill when the user wants to find microarray, RNA-seq, or other genomic data by keywords, organism, author, or specific fields.

Unified CLI/Python interface for querying genomic, proteomic, structure, and expression data across 20+ bioinformatics databases; use when you need fast, scriptable retrieval by gene/protein IDs or keywords.