Designs and scaffolds bioinformatics pipelines using Prefect (Python) with Dask for local/distributed task execution and Nextflow for HPC scheduler-native execution. Use when an agent must choose between Prefect+Dask vs Nextflow, generate runnable project skeletons, or adapt workflows for laptops, workstations, and HPC clusters (e.g., Slurm/PBS) with reproducibility, caching/resume, and resource-aware configuration.