WebXR integration for three.js: WebXRManager and XRManager on the renderer, session initialization patterns, VRButton and ARButton helpers, XRControllerModelFactory and hand model families, XREstimatedLight, XRPlanes, and related addon Webxr utilities. Use for immersive sessions and controller/hand tracking—not for standard desktop camera projection (threejs-camera) or composer post effects (threejs-postprocessing).

Builds Vue 3 mobile UIs in uni-app using the uView Pro component library (100+ components). Covers Button, Form, List, Modal, Tabs, NavBar, plus built-in HTTP, storage, router, and validator utilities. Use when the user needs to create uni-app interfaces with uView Pro, configure themes, or use uView Pro utility tools.

Builds Vue 2 mobile UIs in uni-app using the uView UI component library with Button, Input, Form, Table, Modal, Tabs, and built-in $u tools (toast, http, storage, route). Use when the user needs to create uni-app interfaces with uView UI for Vue 2, customize themes via SCSS variables, or use $u utility methods.

Provides comprehensive guidance for Vue Router including route configuration, navigation, dynamic routes, nested routes, route guards, programmatic navigation, and route meta. Use when the user asks about Vue Router, needs to set up routing, implement navigation guards, handle route parameters, or manage route transitions.

Provides structured guidance for Vant of Vue 3.0. Use when the user needs Vant with Vue 3, asks about mobile UI components such as Button, Cell, Form, Dialog, Toast, Popup, ConfigProvider, theme customization, project setup, or wants to implement mobile-first interfaces with vant or van- components.

Build AI chat interfaces using ai-elements components — conversations, messages, tool displays, prompt inputs, and more. Use when the user wants to build a chatbot, AI assistant UI, or any AI-powered chat interface.

Systematically maps mechanism evidence for a disease from molecules to pathways, cell types, tissues, biological consequences, and clinical phenotypes. Always use this skill when a user needs a layered mechanism evidence chain rather than a flat summary or immediate gap analysis. Formal literature citations must be real and verifiable.

Assesses whether a medical research topic is worth starting now by separating true novelty from pseudo-novelty, auditing real feasibility under stated resource constraints, and forcing a concrete start / narrow / redesign / stop decision. Always require explicit assumptions and never fabricate references, datasets, resource availability, precedent studies, or publication claims.

Precision editing tool that reduces abstract word count through intelligent compression techniques, maintaining scientific rigor while meeting strict journal and conference requirements.

1. Confirm the user objective, required inputs, and non-negotiable constraints before doing detailed work. 2. Validate that the request matches the documented scope and stop early if the task would require unsupported as.

1. Confirm the user objective, required inputs, and non-negotiable constraints before doing detailed work. 2. Validate that the request matches the documented scope and stop early if the task would require unsupported as.

1. Confirm the user objective, required inputs, and non-negotiable constraints before doing detailed work. 2. Validate that the request matches the documented scope and stop early if the task would require unsupported as.

Converts LabArchives notebook data, entry metadata, and authorized ELN exports into manuscript-ready academic writing outputs such as Methods sections, data-availability statements, reproducibility appendices, experiment timelines, and submission support notes. Optional bundled scripts can be used to collect or validate source notebook data before writing.

Write and revise the Methods section of research papers to ensure reproducibility; use when preparing an IMRAD manuscript or responding to journal/reporting-guideline requirements (e.g., CONSORT/STROBE/PRISMA).

Assists R&D teams with patent technical disclosure drafting and patent/novelty search analysis; use when users ask to write a patent disclosure, structure an invention description, search related patents, or assess novelty.

Constraint-based reconstruction and analysis (COBRA) for metabolic models; use when you need to simulate growth/production, analyze flux ranges, or run knockout and medium studies from SBML/JSON/YAML models.

Machine learning toolkit for genomic interval (BED) data; use it when you need to tokenize BED collections and train embeddings for regions/cells/labels, build consensus peak universes, or run similarity search and downstream ML on chromatin accessibility datasets.

Analyzes the feasibility of a proposed Meta-analysis topic by searching for existing Meta-analyses and Clinical Trials on PubMed/ClinicalTrials.gov. Use when you need to evaluate if a topic is viable for a new Meta-analysis.

Screen full-text papers against inclusion/exclusion criteria, with optional PubMed metadata check using PMID. Use when the user needs to evaluate a paper for a meta-analysis.

Access NIH Metabolomics Workbench (4,200+ studies) via REST API. Query metabolites, RefMet nomenclature, MS/NMR data, m/z search, study metadata for metabolomics and biomarker discovery.

> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

Infer gene regulatory networks (GRNs) from gene expression matrices using GRNBoost2 or GENIE3; use when analyzing bulk or single-cell RNA-seq to identify TF→target regulatory relationships.

Accesses BioGRID ORCS CRISPR screen data (organisms, screens, scores). Invoke when user needs to search CRISPR screens, get vocabulary, or retrieve gene scores.

Programmatically query the CZ CELLxGENE Census (61M+ cells) when you need cross-tissue, disease, or cell-type expression data for population-scale queries and reference atlas comparisons.

Access ClinPGx pharmacogenomics data (successor to PharmGKB) when you need to query gene-drug interactions, CPIC guidelines, allele functions, and drug-label PGx content for precision medicine and genotype-guided dosing.

Accesses Comparative Toxicogenomics Database (CTD) for chemical, gene, disease, and pathway interaction data. Invoke when user needs to query CTD, retrieve toxicogenomics data, or investigate chemical-disease relationships.

Access Ensembl REST API for vertebrate genomic data; use when you need gene/ID lookups, sequence retrieval, variant effect prediction (VEP), or homology/assembly coordinate mapping.

Analyze funding abstracts and project metadata to identify topic shifts and forecast near-term grant priorities.

Access the KEGG database API to retrieve biological data (genes, pathways, compounds, drugs). Invoke when the user asks to search, list, or get details from KEGG.

Query the Open Targets Platform to retrieve targets, diseases, or evidence records when you need target-disease association data and evidence-based scores for therapeutic discovery.

Access the OpenAlex database (240M+ scholarly works) for bibliometric analysis, literature search, and citation tracking; use when you need to query works/authors/institutions/concepts without an API key.

Programmatic access to the PubChem database (via PUG-REST API and PubChemPy) for searching chemical compounds, retrieving physicochemical properties, performing structure similarity/substructure searches, and obtaining bioactivity data.

Query the Reactome REST API for pathway content and enrichment analyses; use when you need curated pathway data, reaction details, or overrepresentation results for a gene list.

Integrate with the Benchling R&D platform when you need to programmatically manage registry entities, inventory, ELN entries, workflows, events, or data warehouse analytics via API/SDK.

Calculate precise buffer recipes with accurate mass and volume measurements for molecular biology and biochemistry. Supports PBS, RIPA, and TAE with concentration scaling, stock solution preparation, pH adjustment guidance, and step-by-step protocols.

De-identify DICOM medical images by removing PHI tags for research sharing, with audit logging and study-linkage preservation support.

Check if images meet 300 DPI printing standards, and intelligently restore blurry low-resolution images using AI super-resolution technology.

Perform fast file name and content searches with ripgrep (rg); use it when you need to locate files by glob/regex, find keywords across directories, or replace common find/grep workflows.

A toolkit for preparing ISO 13485:2016 certification documentation for medical device QMS. Use when you need to perform a documentation gap analysis, draft or update a Quality Manual, create required procedures/work instructions, build Medical Device Files (MDF), interpret ISO 13485 clauses, or identify missing documents for certification (often triggered by ISO 13485, QMS certification, FDA QMSR, EU MDR, or quality system documentation requests).

Filter and match postdoctoral fellowship opportunities based on applicant nationality, years since PhD, and research field from a curated database.

An intelligent tool for precision medical literature search using PubMed's E-utilities API.

Toolkit for protein language models (ESM3 for multimodal generative protein design; ESM C for efficient embeddings). Use when you need sequence/structure/function generation or prediction, inverse folding, protein embeddings, or scalable inference via local weights or the Forge API.

> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

dpia-sentinel-oliver-schmidt-prietz

Build and solve Walrasian general equilibrium models with theory derivations and Julia computation

Full autonomous research workflow using swarm mode for parallel execution

Create new Beamer lecture from papers and materials. Guided workflow with notation consistency.

Create and compile beautiful Beamer presentations following the Rhetoric of Decks philosophy. Use when making slides, creating decks, or compiling .tex presentation files.

Run a comprehensive consistency audit across the entire repository, fix all issues found, and loop until clean.

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