12 regulatory & QM agent skills and plugins for Claude Code, Codex, Gemini CLI, Cursor, OpenClaw. ISO 13485 QMS, MDR 2017/745, FDA 510(k)/PMA, ISO 27001 ISMS, GDPR/DSGVO, risk management (ISO 14971), CAPA, document control, auditing. Python tools (stdlib-only).

Use when the user asks to prepare for SOC 2 audits, map Trust Service Criteria, build control matrices, collect audit evidence, perform gap analysis, or assess SOC 2 Type I vs Type II readiness.

Fill out a job application on Greenhouse, Lever, or Workday

Search for jobs matching my resume and preferences

Systematically deconstruct written content into verifiable claims, validate each using search/documentation, and facilitate informed discussion through structured interviewing.

Redis-backed SSE stream management with stream registry, heartbeat monitoring, completion store for terminal events, and automatic orphan cleanup via background guardian process.

Universal planning for technical and non-technical projects. Domains: software implementation, business, personal, creative, academic, events. Capabilities: feature planning, system architecture, goal setting, milestone planning, requirement breakdown, trade-off analysis, resource allocation, risk assessment. Actions: plan, architect, design, evaluate, breakdown, structure projects. Keywords: implementation plan, technical design, architecture, roadmap, project plan, strategy, goal setting, milestones, timeline, action plan, SMART goals, sprint planning, task breakdown, OKRs. Use when: planning features, designing architecture, creating roadmaps, setting goals, organizing projects, breaking down requirements.

**Core Principle:** Orchestrate skills dynamically. Analyze the task, discover available skills, build the right chain, explain the reasoning, execute step-by-step with confirmation.

PRD 驱动的任务调度与技能管理专家。接收完整 PRD/需求文档，负责拆解业务、选择技术栈、路由到合适的专业 Skill，并维护从方案到落地的全流程。

[01] META. Сканирует доступные skills, создает план выполнения и идет шаг за шагом с подтверждением каждого этапа. Triggers on complex tasks, multi-step work, or when structured execution is needed.

Git 版本控制与协作专家，涵盖 GitHub/Gitee 平台操作、Conventional Commits 规范及 PR/MR 最佳实践。

Establish clarity before starting work. Use when beginning any significant task, when input is vague or stream-of-consciousness, or when requirements seem unclear. Handles messy voice input efficiently. This is the first system in the 5-system framework.

A personal knowledge base for **building understanding that compounds over time**. Not a note dump - a structured system for capturing knowledge you can actually retrieve and use.

The Twelve-Factor App methodology for building scalable, maintainable cloud-native applications. Use when designing backend services, APIs, microservices, or any software-as-a-service application. Triggers on deployment patterns, configuration management, process architecture, logging, and infrastructure decisions.

This skill identifies novel transcription factor binding motifs in the promoter regions of genes, or directly from genomic regions of interest such as ChIP-seq peaks, ATAC-seq accessible sites, or differentially acessible regions. It employs HOMER (Hypergeometric Optimization of Motif Enrichment) to detect both known and previously uncharacterized sequence motifs enriched within the supplied genomic intervals. Use the skill when you need to uncover sequence motifs enriched or want to know which TFs might regulate the target regions.

This skill should be used when users need to perform known motif enrichment analysis on ChIP-seq, ATAC-seq, or other genomic peak files using HOMER (Hypergeometric Optimization of Motif EnRichment). It identifies enrichment of known transcription factor binding motifs from established databases in genomic regions.

Automatically detect and normalize Hi-C data. Only .cool or .mcool file is supported. All .mcool files are then checked for existing normalization (supports bins/weight only) and balanced if none of the normalizations exist.

Guide for adding new blockchain chains to OneKey. Use when implementing new chain support, adding blockchain protocols, or understanding chain architecture. Triggers on chain, blockchain, protocol, network, coin, token, add chain, new chain.

OneKey monorepo architecture and code organization. Use when understanding project structure, package relationships, import rules, or component organization. Triggers on architecture, structure, packages, imports, hierarchy, dependencies, monorepo, organization.

Coding patterns and best practices for OneKey development. Use when writing React components, handling promises, error handling, or following code conventions. Triggers on react, component, hooks, promise, async, await, error, pattern, convention, typescript.

Interactive guide for integrating new DeFi modules or protocols into OneKey. Use when adding new DeFi features like staking protocols, lending markets, or entirely new DeFi modules. Triggers on DeFi, protocol, integration, Earn, Borrow, staking, lending, supply, borrow, withdraw, repay, claim, new module, Pendle, Aave, Compound.

Feature development guides for OneKey. Use when adding new chains, socket events, notifications, pages, or routes. Covers blockchain integration, WebSocket subscriptions, push notifications, and navigation patterns.

Documents minimum SDK/OS version requirements for all OneKey platforms. Use when checking platform compatibility, understanding deployment targets, verifying version requirements, or when user asks if their device can run the project. Triggers on minimum version, SDK version, API level, deployment target, platform requirements, iOS version, Android version, Chrome version, Electron version, can I run, environment check, device compatibility, check environment.

Use this skill when working with the 1Password CLI (`op` command) for secrets management, retrieving API keys, or injecting secrets into development environments.

This skill performs differential topologically associating domain (TAD) analysis using HiCExplorer's hicDifferentialTAD tool. It compares Hi-C contact matrices between two conditions based on existing TAD definitions to identify significantly altered chromatin domains.

[21] UNDERSTAND. Deep research workflow for this project using 150% scope (100% core + 50% boundary), evidence-based reasoning, and structured investigation notes. Use when the task requires investigation, root-cause analysis, or mapping unknown areas. Always maintain a research log file that captures findings, hypotheses, and next branches; use web.run when external verification is needed.

This skill provides a complete and streamlined workflow for performing methylation variability and epigenetic heterogeneity analysis from whole-genome bisulfite sequencing (WGBS) data. It is designed for researchers who want to quantify CpG-level variability across biological samples or conditions, identify highly variable CpGs (HVCs), and explore epigenetic heterogeneity.

You are an expert in 2D bin packing and rectangular packing optimization. Your goal is to help pack rectangular items into 2D bins or sheets while minimizing waste, number of bins used, or maximizing

You are an expert in two-dimensional cutting stock problems and rectangular sheet optimization. Your goal is to help minimize material waste and costs when cutting large sheets (steel plates, glass pa

Creates high-quality content (blog posts, tweets, newsletters, documentation) that matches the user's writing style and voice. Performs web research to find citations and supporting evidence. Use when user requests blog posts, marketing content, newsletters, tweets, or any written content that should sound authentic and be well-researched.

Third step in building instruction context for codebase

Status: ACTIVE

Use when working in Blender, Unity 3D, Unreal Engine, Cinema 4D, VR/AR applications, or any three-dimensional animation work.

Protect your SaaS app from common vulnerabilities. Use when building auth, handling user data, or deploying features. Covers authentication, data protection, API security, and OWASP Top 10 for non-technical founders using AI tools.

Create a relational-db-agent skill that knows SQLModel async patterns

[50] EXECUTE. Execute plans step-by-step with confirmation gates. Each step requires user approval before proceeding. Includes change management lifecycle (Pre-Change → During → Post-Change → Rollback). Use when implementing approved plans, deploying changes, or any multi-step execution requiring control and reversibility.

Perform iterative root cause analysis by asking "why" repeatedly until you reach the underlying cause.

Guides consistent, correct implementation of Stripe payment processing including payment flows, webhooks, subscriptions, and customer management. Use when integrating Stripe payments, setting up subscriptions, implementing webhooks, or managing customer billing.

Create your llmops-fine-tuner skill from Unsloth documentation before learning fine-tuning theory

You're about to learn persona fine-tuning. But here's the pattern that will make this knowledge truly yours: **build the skill BEFORE you learn the content**.

Before diving into tool-calling patterns, structured outputs, and JSON accuracy metrics, you'll build the skill that will guide your learning throughout this chapter. This isn't just preparation—it's

Create your model-alignment skill from TRL documentation before learning DPO theory

Create your model-serving skill from Ollama documentation before learning deployment theory

Create your agent-integration skill from OpenAI SDK and LiteLLM documentation before learning framework integration

[71] CLOSE. Quick, safe cleanup after completing a milestone. Fix objective issues only (syntax errors, dead code, poor naming). Must be <5% of main task time, <30 seconds per fix, and reversible. Use after key points, not after every small change.

**Core Principle:** Never lose progress. Save context before ending, restore context when starting.

[74] CLOSE. Quick checkpoint during active work when context is running low. Use multiple times per development cycle to preserve progress and lessons. Lighter than close-session — no full handoff needed. Triggers on 'save progress', 'checkpoint', 'context low', or automatically when nearing token limits.

8claw is an anonymous imageboard built for AI agents. Have discussions with other AI agents anonymously.

AI Manipulation Defense System implementation with Midstream, AgentDB, and lean-agentic

Epic EMR consulting workflows for ClinDoc, Bridges, interfaces, and clinical builds. USE WHEN user mentions Epic, orderset, ClinDoc, Bridges, interface, HL7, provider matching, VersaCare, ScottCare, OR any client name (Memphis, Raleigh, Orlando, Nova, Baptist).