Status: ACTIVE

This skill performs A/B compartment shift analysis between two Hi-C samples.

This skill annotates chromatin loops, including enhancer/promoter assignments, CTCF-peak overlap. It automatically constructs enhancer and promoter sets when missing and outputs standardized loop categories.

Deep knowledge expert for the 33GOD agentic pipeline system, understands component relationships and suggests feature implementations based on actual codebase state

Create your OpenAI Agents SDK skill in one prompt, then learn to improve it throughout the chapter

Status: ACTIVE

Create your Claude Agent SDK skill in one prompt, then learn to improve it throughout the chapter

Apply 37signals/DHH Rails conventions when writing Ruby on Rails code. Use when building Rails applications, reviewing Rails code, or making architectural decisions. Covers various aspects of Rails application architecture, design and dependencies.

Create your MCP server building skill in one prompt, then learn to improve it throughout the chapter

Build a specification-first Digital FTE that orchestrates accumulated intelligence from Lessons 1-7. Learn to compose execution skills into production-ready agents, validate against specifications, and position for monetization.

Create a skill that orchestrates the write-execute-analyze loop to autonomously process data. Learn to implement error recovery, iterate toward robust solutions, and test your skill across diverse input scenarios. This is where specification-driven development meets real problem-solving.

You are an expert in 3D bin packing and three-dimensional space optimization. Your goal is to help pack 3D boxes and items into containers, trucks, or bins while maximizing space utilization, minimizi

Three.js 3D building system with spatial indexing, structural physics, and multiplayer networking. Use when creating survival games, sandbox builders, or any game with player-constructed structures. Covers performance optimization (spatial hash grids, octrees, chunk loading), structural validation (arcade/heuristic/realistic physics modes), and multiplayer sync (delta compression, client prediction, conflict resolution).

Complete Three.js building system with spatial indexing, structural physics, and multiplayer networking. Use for survival/crafting games, sandbox games, multiplayer construction, or any 3D building mechanics.

Expert in 3D computer vision labeling tools, workflows, and AI-assisted annotation for LiDAR, point clouds, and sensor fusion. Covers SAM4D/Point-SAM, human-in-the-loop architectures, and vertical-specific training strategies. Activate on '3D labeling', 'point cloud annotation', 'LiDAR labeling', 'SAM 3D', 'SAM4D', 'sensor fusion annotation', '3D bounding box', 'semantic segmentation point cloud'. NOT for 2D image labeling (use clip-aware-embeddings), general ML training (use ml-engineer), video annotation without 3D (use computer-vision-pipeline), or VLM prompt engineering (use prompt-engineer).

3D game development principles. Rendering, shaders, physics, cameras.

3D web graphics with Three.js (WebGL/WebGPU). Capabilities: scenes, cameras, geometries, materials, lights, animations, model loading (GLTF/FBX), PBR materials, shadows, post-processing (bloom, SSAO, SSR), custom shaders, instancing, LOD, physics, VR/XR. Actions: create, build, animate, render 3D scenes/models. Keywords: Three.js, WebGL, WebGPU, 3D graphics, scene, camera, geometry, material, light, animation, GLTF, FBX, OrbitControls, PBR, shadow mapping, post-processing, bloom, SSAO, shader, instancing, LOD, WebXR, VR, AR, product configurator, data visualization, architectural walkthrough, interactive 3D, canvas. Use when: creating 3D visualizations, building WebGL/WebGPU apps, loading 3D models, adding animations, implementing VR/XR, creating interactive graphics, building product configurators.

**Role**: Senior 3D Artist / Technical Artist

Use when working in Blender, Unity 3D, Unreal Engine, Cinema 4D, VR/AR applications, or any three-dimensional animation work.

Expert in Three.js, 3D graphics, and interactive 3D visualizations

Expert in building 3D experiences for the web - Three.js, React Three Fiber, Spline, WebGL, and interactive 3D scenes. Covers product configurators, 3D portfolios, immersive websites, and bringing depth to web experiences. Use when: 3D website, three.js, WebGL, react three fiber, 3D experience.

Performs ATAC-specific biological validation. It calculates metrics unique to chromatin accessibility assays, such as TSS enrichment scores and fragment size distributions (nucleosome banding patterns). Use this skill when you have filtered BAM file and have called peak for the file. Do NOT use this skill for ChIP-seq data or general alignment statistics.

Fourth step in building instruction context for codebase

Execute tasks with velocity and quality. Use when ready to implement after clarity and prioritization are complete. This is the fourth system in the 5-system framework.

Researches and identifies potential customers, leads, and business opportunities for your product or service. Analyzes your offering, finds relevant companies and decision makers, provides contact information, and suggests outreach strategies. Use when looking for leads, researching target customers, identifying decision makers, or planning sales outreach.

Protect your SaaS app from common vulnerabilities. Use when building auth, handling user data, or deploying features. Covers authentication, data protection, API security, and OWASP Top 10 for non-technical founders using AI tools.

Coordinator workflow for orchestrating dockeragents through fix-review-iterate-present loop. Use when delegating any task that produces code changes. Ensures agents achieve 10/10 quality before presenting to human.

Create your FastAPI skill in one prompt, then learn to improve it throughout the chapter

**Core Principle:** Know the path before walking. Have clear steps, know what success looks like, and be ready for what could go wrong.

Create your ChatKit Server skill in one prompt, then learn to improve it throughout the chapter

Create your OpenAI Apps SDK skill in one prompt, then learn to improve it throughout the chapter

Create your RAG skill in one prompt, then learn to improve it throughout the chapter

Create a relational-db-agent skill that knows SQLModel async patterns

Create your agent-tdd skill in one prompt, then learn to improve it throughout the chapter

Create your agent-evals skill from official documentation before learning evaluation concepts. This skill-first approach ensures you build production-ready evaluation capabilities grounded in authoritative sources.

Validate your agent-evals skill by testing it on a completely different agent. A skill proves its worth when it transfers beyond the context where you learned it.

Transform Docker knowledge from Lessons 1-6 into a reusable AI skill for consistent, production-ready containerization

Create your Docker deployment skill in one prompt, then learn to improve it throughout the chapter

4claw — a moderated imageboard for AI agents. Boards, threads, replies, media uploads, bumping (bump=false to not bump), greentext, and automatic capacity purges. Post spicy hot takes (what you're REALLY thinking) — but no illegal content, doxxing, harassment, or minors.

World-class #1 expert 4PL and supply chain director specializing in AI-powered logistics optimization, digital transformation, warehouse automation, transportation management systems (TMS), inventory optimization algorithms, 3PL/4PL strategic partnerships, supply chain analytics, and global logistics operations. Use for any supply chain strategy, warehouse operations, route optimization, demand forecasting, or logistics technology decisions.

Performs ChIP-specific biological validation. It calculates metrics unique to protein-binding assays, such as Cross-correlation (NSC/RSC) and FRiP. Use this when you have filtered the BAM file and called peaks for ChIP-seq data. Do NOT use this skill for ATAC-seq data or general alignment statistics.

Brainstorms creative domain names for projects and checks availability across common TLDs (.com, .ai, .dev, .io, .app). Saves hours of manual searching. Use when starting a new project and need a domain name, or when rebranding existing projects.

Optimize your SaaS app across four dimensions - Speed (page load, API response), Code (unused files, dead code), Database (orphaned data, schema hygiene), and Dependencies (package bloat, bundle size). Use when app feels slow, codebase feels bloated, or after significant development work accumulates. Each path follows AUDIT → CLEAN → PREVENT workflow.

Reset after failures, blockers, or when stuck. Use when execution hits a wall, something breaks, or we need to step back and reassess. This is the fifth system in the 5-system framework.

Fifth step in building instruction context for codebase

[50] EXECUTE. Execute plans step-by-step with confirmation gates. Each step requires user approval before proceeding. Includes change management lifecycle (Pre-Change → During → Post-Change → Rollback). Use when implementing approved plans, deploying changes, or any multi-step execution requiring control and reversibility.

Create your Kubernetes deployment skill in one prompt, then learn to improve it throughout the chapter

You built your Kubernetes skill in Lesson 0 and refined it through Lessons 1-14. Now validate that it actually transfers to new projects.

**Core Principle:** Commit to excellence. Work at 150% — 100% core delivery + 50% strengthening through verification, alternatives, and risk awareness.

Create your Helm chart skill in one prompt, then learn to improve it throughout the chapter