Implement data quality validation with Great Expectations, dbt tests, and data contracts. Use when building data quality pipelines, implementing validation rules, or establishing data contracts.

Master dbt (data build tool) for analytics engineering with model organization, testing, documentation, and incremental strategies. Use when building data transformations, creating data models, or implementing analytics engineering best practices.

Master end-to-end testing with Playwright and Cypress to build reliable test suites that catch bugs, improve confidence, and enable fast deployment. Use when implementing E2E tests, debugging flaky tests, or establishing testing standards.

Master advanced Git workflows including rebasing, cherry-picking, bisect, worktrees, and reflog to maintain clean history and recover from any situation. Use when managing complex Git histories, collaborating on feature branches, or troubleshooting repository issues.

Master monorepo management with Turborepo, Nx, and pnpm workspaces to build efficient, scalable multi-package repositories with optimized builds and dependency management. Use when setting up monorepos, optimizing builds, or managing shared dependencies.

Generate and maintain OpenAPI 3.1 specifications from code, design-first specs, and validation patterns. Use when creating API documentation, generating SDKs, or ensuring API contract compliance.

Use when writing technical documentation that needs to be readable by both humans and AI models, converting existing docs to HADS format, validating a HADS document, or optimizing documentation for token-efficient AI consumption.

Manage major dependency version upgrades with compatibility analysis, staged rollout, and comprehensive testing. Use when upgrading framework versions, updating major dependencies, or managing breaking changes in libraries.

Upgrade React applications to latest versions, migrate from class components to hooks, and adopt concurrent features. Use when modernizing React codebases, migrating to React Hooks, or upgrading to latest React versions.

Create structured incident response runbooks with step-by-step procedures, escalation paths, and recovery actions. Use this skill when building a service outage runbook for a payment processing system; creating database incident procedures covering connection pool exhaustion, replication lag, and disk space alerts; onboarding new on-call engineers who need step-by-step recovery guides written for a 3 AM brain; or standardizing escalation matrices across multiple engineering teams.

Implement comprehensive testing strategies using Jest, Vitest, and Testing Library for unit tests, integration tests, and end-to-end testing with mocking, fixtures, and test-driven development. Use when writing JavaScript/TypeScript tests, setting up test infrastructure, or implementing TDD/BDD workflows.

Select and optimize embedding models for semantic search and RAG applications. Use when choosing embedding models, implementing chunking strategies, or optimizing embedding quality for specific domains.

Combine vector and keyword search for improved retrieval. Use when implementing RAG systems, building search engines, or when neither approach alone provides sufficient recall.

Implement comprehensive evaluation strategies for LLM applications using automated metrics, human feedback, and benchmarking. Use when testing LLM performance, measuring AI application quality, or establishing evaluation frameworks.

PluginEval quality methodology — dimensions, rubrics, statistical methods, and scoring formulas. Use this skill when understanding how plugin quality is measured, when interpreting a low score on a specific dimension, when deciding how to improve a skill's triggering accuracy or orchestration fitness, when calibrating scoring thresholds for your marketplace, or when explaining quality badges to external partners like Neon.

Python configuration management via environment variables and typed settings. Use when externalizing config, setting up pydantic-settings, managing secrets, or implementing environment-specific behavior.

Implement comprehensive testing strategies with pytest, fixtures, mocking, and test-driven development. Use when writing Python tests, setting up test suites, or implementing testing best practices.

Build robust backtesting systems for trading strategies with proper handling of look-ahead bias, survivorship bias, and transaction costs. Use when developing trading algorithms, validating strategies, or building backtesting infrastructure.

Master network protocol reverse engineering including packet analysis, protocol dissection, and custom protocol documentation. Use when analyzing network traffic, understanding proprietary protocols, or debugging network communication.

Build comprehensive attack trees to visualize threat paths. Use when mapping attack scenarios, identifying defense gaps, or communicating security risks to stakeholders.

Configure Static Application Security Testing (SAST) tools for automated vulnerability detection in application code. Use when setting up security scanning, implementing DevSecOps practices, or automating code vulnerability detection.

Derive security requirements from threat models and business context. Use when translating threats into actionable requirements, creating security user stories, or building security test cases.

Master Bash Automated Testing System (Bats) for comprehensive shell script testing. Use when writing tests for shell scripts, CI/CD pipelines, or requiring test-driven development of shell utilities.

Add Telegram channel integration via Chat SDK.

Browse the web for any task — research topics, read articles, interact with web apps, fill forms, take screenshots, extract data, and test web pages. Use whenever a browser would be useful, not just when the user explicitly asks.

Pro frontend engineering discipline. Enforces build-test-verify workflow for every web project. Never declare done until the site is built, tested, responsive, accessible, and visually verified in a real browser. Use alongside vercel-cli for production-quality deployments.

This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based guidelines with decision algorithms). Supports GRADE evidence grading, statistical analysis (hazard ratios, survival curves, waterfall plots), biomarker integration, and regulatory compliance. Outputs publication-ready LaTeX/PDF format optimized for drug development, clinical research, and evidence synthesis.

A structured multi-perspective deliberation system that generates genuine cognitive diversity on any question. Instead of one voice giving one answer, the Council summons distinct thinking archetypes

Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first PyTorch workflows use torchdrug; for benchmark datasets use pytdc.

Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.

Perform comprehensive exploratory data analysis on scientific data files across 200+ file formats. This skill should be used when analyzing any scientific data file to understand its structure, content, quality, and characteristics. Automatically detects file type and generates detailed markdown reports with format-specific analysis, quality metrics, and downstream analysis recommendations. Covers chemistry, bioinformatics, microscopy, spectroscopy, proteomics, metabolomics, and general scientific data formats.

Framework for computational fluid dynamics simulations using Python. Use when running fluid dynamics simulations including Navier-Stokes equations (2D/3D), shallow water equations, stratified flows, or when analyzing turbulence, vortex dynamics, or geophysical flows. Provides pseudospectral methods with FFT, HPC support, and comprehensive output analysis.

Comprehensive geospatial science skill covering remote sensing, GIS, spatial analysis, machine learning for earth observation, and 30+ scientific domains. Supports satellite imagery processing (Sentinel, Landsat, MODIS, SAR, hyperspectral), vector and raster data operations, spatial statistics, point cloud processing, network analysis, cloud-native workflows (STAC, COG, Planetary Computer), and 8 programming languages (Python, R, Julia, JavaScript, C++, Java, Go, Rust) with 500+ code examples. Use for remote sensing workflows, GIS analysis, spatial ML, Earth observation data processing, terrain analysis, hydrological modeling, marine spatial analysis, atmospheric science, and any geospatial computation task.

High-performance toolkit for genomic interval analysis in Rust with Python bindings. Use when working with genomic regions, BED files, coverage tracks, overlap detection, tokenization for ML models, or fragment analysis in computational genomics and machine learning applications.

Automated LLM-driven hypothesis generation and testing on tabular datasets. Use when you want to systematically explore hypotheses about patterns in empirical data (e.g., deception detection, content analysis). Combines literature insights with data-driven hypothesis testing. For manual hypothesis formulation use hypothesis-generation; for creative ideation use scientific-brainstorming.

Structured hypothesis formulation from observations. Use when you have experimental observations or data and need to formulate testable hypotheses with predictions, propose mechanisms, and design experiments to test them. Follows scientific method framework. For open-ended ideation use scientific-brainstorming; for automated LLM-driven hypothesis testing on datasets use hypogenic.

Create professional research posters in LaTeX using beamerposter, tikzposter, or baposter. Support for conference presentations, academic posters, and scientific communication. Includes layout design, color schemes, multi-column formats, figure integration, and poster-specific best practices for visual communication.

Spectral similarity and compound identification for metabolomics. Use for comparing mass spectra, computing similarity scores (cosine, modified cosine), and identifying unknown compounds from spectral libraries. Best for metabolite identification, spectral matching, library searching. For full LC-MS/MS proteomics pipelines use pyopenms.

Low-level plotting library for full customization. Use when you need fine-grained control over every plot element, creating novel plot types, or integrating with specific scientific workflows. Export to PNG/PDF/SVG for publication. For quick statistical plots use seaborn; for interactive plots use plotly; for publication-ready multi-panel figures with journal styling, use scientific-visualization.

Comprehensive toolkit for creating, analyzing, and visualizing complex networks and graphs in Python. Use when working with network/graph data structures, analyzing relationships between entities, computing graph algorithms (shortest paths, centrality, clustering), detecting communities, generating synthetic networks, or visualizing network topologies. Applicable to social networks, biological networks, transportation systems, citation networks, and any domain involving pairwise relationships.

Official Opentrons Protocol API for OT-2 and Flex robots. Use when writing protocols specifically for Opentrons hardware with full access to Protocol API v2 features. Best for production Opentrons protocols, official API compatibility. For multi-vendor automation or broader equipment control use pylabrobot.

You have access to 10 academic paper databases through their REST APIs. Your job is to figure out which database(s) best serve the user's query, call them, and return the results.

Chat with your agent about projects, recommendations, and canonical papers in Paperzilla. Use when users ask for recent project recommendations, canonical paper details, markdown-based summaries, recommendation feedback, feed export, or Atom feed URLs.

Hardware-agnostic quantum ML framework with automatic differentiation. Use when training quantum circuits via gradients, building hybrid quantum-classical models, or needing device portability across IBM/Google/Rigetti/IonQ. Best for variational algorithms (VQE, QAOA), quantum neural networks, and integration with PyTorch/JAX/TensorFlow. For hardware-specific optimizations use qiskit (IBM) or cirq (Google); for open quantum systems use qutip.

High-performance genomic interval operations and bioinformatics file I/O on Polars DataFrames. Overlap, nearest, merge, coverage, complement, subtract for BED/VCF/BAM/GFF intervals. Streaming, cloud-native, faster bioframe alternative.

Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.

Comprehensive healthcare AI toolkit for developing, testing, and deploying machine learning models with clinical data. This skill should be used when working with electronic health records (EHR), clinical prediction tasks (mortality, readmission, drug recommendation), medical coding systems (ICD, NDC, ATC), physiological signals (EEG, ECG), healthcare datasets (MIMIC-III/IV, eICU, OMOP), or implementing deep learning models for healthcare applications (RETAIN, SafeDrug, Transformer, GNN).

Complete mass spectrometry analysis platform. Use for proteomics workflows feature detection, peptide identification, protein quantification, and complex LC-MS/MS pipelines. Supports extensive file formats and algorithms. Best for proteomics, comprehensive MS data processing. For simple spectral comparison and metabolite ID use matchms.

Genomic file toolkit. Read/write SAM/BAM/CRAM alignments, VCF/BCF variants, FASTA/FASTQ sequences, extract regions, calculate coverage, for NGS data processing pipelines.