This skill performs chromatin loop detection from Hi-C .mcool files using cooltools.

Adds new WebSocket event subscriptions to OneKey. Use when implementing new socket events, handling server push messages, or adding real-time data subscriptions. Socket, WebSocket, event, subscription, push, real-time.

Create test versions to verify app auto-update functionality. Use when testing update flows, version migration, or validating app upgrade mechanisms. Automates version number and build number configuration for testing the auto-update system. Triggers on auto update, app upgrade, update testing, upgrade flow, version migration, test build, 9XXX version.

OneKey monorepo architecture and code organization. Use when understanding project structure, package relationships, import rules, or component organization. Triggers on architecture, structure, packages, imports, hierarchy, dependencies, monorepo, organization.

Coding patterns and best practices for OneKey development. Use when writing React components, handling promises, error handling, or following code conventions. Triggers on react, component, hooks, promise, async, await, error, pattern, convention, typescript.

Interactive guide for integrating new DeFi modules or protocols into OneKey. Use when adding new DeFi features like staking protocols, lending markets, or entirely new DeFi modules. Triggers on DeFi, protocol, integration, Earn, Borrow, staking, lending, supply, borrow, withdraw, repay, claim, new module, Pendle, Aave, Compound.

Development commands for OneKey monorepo. Use when running dev servers, building apps, linting, testing, or troubleshooting build issues. Triggers on yarn, dev, build, lint, test, desktop, mobile, web, extension, ios, android, compile, bundle.

Error handling patterns and best practices for OneKey. Use when implementing try/catch blocks, handling async errors, showing error messages, or managing error states in UI. Triggers on error, try, catch, exception, throw, fail, failure, error handling, error boundary, useAsyncCall, toast, fallback, error state.

Git workflow and conventions for OneKey development. Use when creating branches, committing code, or creating PRs. Triggers on git, branch, commit, PR, pull request, merge, workflow.

Creates a new Claude Code Skill following best practices. Use when the user wants to create a new skill, add a skill, or asks about writing skills for Claude Code. Fetches latest documentation before generating skill content. New skill. Create a skill.

Patches native modules (expo-image, react-native, etc.) to fix native crashes or bugs.

Performance optimization guidelines for OneKey React/React Native applications. Use when optimizing app performance, fixing UI freezes/lag, reducing re-renders, handling concurrent operations, or analyzing performance bottlenecks. Triggers on performance, optimization, optimize, slow, lag, freeze, hang, jank, stutter, memory, leak, concurrent, batching, batch, memoization, memo, bridge, windowSize, contentVisibility, FlashList, re-render, fps, tti, bundle.

Documents minimum SDK/OS version requirements for all OneKey platforms. Use when checking platform compatibility, understanding deployment targets, verifying version requirements, or when user asks if their device can run the project. Triggers on minimum version, SDK version, API level, deployment target, platform requirements, iOS version, Android version, Chrome version, Electron version, can I run, environment check, device compatibility, check environment.

Sentry error tracking and monitoring for OneKey. Use when configuring Sentry, filtering errors, analyzing crash reports, or debugging production issues. Covers platform-specific setup (desktop/mobile/web/extension) and error filtering strategies.

Configures 1Password CLI with direnv for fast, secure credential loading. Activates for: 1Password + direnv setup, slow secrets (>2 sec), .env.op files, op:// references, AWS credentials via env vars, --reveal flag issues, repeated biometric prompts, creating 1Password items programmatically, op item get errors. Not for: 1Password GUI usage, SSH keys (use 1Password SSH agent).

1password-secrets

Create and manage project-specific design systems for SaaS applications. Use when starting a new app (CREATE mode), updating an existing design system (MODIFY mode), or building features that need to follow established patterns (WORK WITHIN mode). Outputs to instructions/design-system.md as the single source of truth for all UX/UI decisions.

This skill performs differential topologically associating domain (TAD) analysis using HiCExplorer's hicDifferentialTAD tool. It compares Hi-C contact matrices between two conditions based on existing TAD definitions to identify significantly altered chromatin domains.

Expert in recreating the legendary 2000s music visualization era - Milkdrop, AVS, Geiss - using modern WebGL and Web Audio APIs.

🍆👾 CHAOS SPAWN - Maximum jank energy skill generated from pure chaos

This skill analyzes the local DNA methylation profiles around target genomic regions provide by user. Use this skill when you want to vasulize the average methylation profile around target regions (e.g. TSS, CTCF peak or other target regions).

**Core Principle:** Research deeply from ALL sources — internal context AND external knowledge. Don't limit yourself to one world.

This skill performs correlation analysis between differential methylation and differential gene expression, identifying genes with coordinated epigenetic regulation. It provides preprocessing and integration workflows, using promoter-level methylation–expression relationships.

This skill provides a complete pipeline for integrating CpG methylation data with chromatin features such as ATAC-seq signal, H3K27ac, H3K4me3, or other histone marks/TF signals.

This skill performs transcription factor (TF) footprint analysis using TOBIAS on ATAC-seq data. It corrects Tn5 sequence bias, quantifies TF occupancy at motif sites, generates footprint scores, and optionally compares differential TF binding across conditions.

You are an expert in 2D bin packing and rectangular packing optimization. Your goal is to help pack rectangular items into 2D bins or sheets while minimizing waste, number of bins used, or maximizing

2D game development principles. Sprites, tilemaps, physics, camera.

Build features with AI coding tools (Claude Code, Lovable, Replit, Cursor). Use when implementing specs, iterating on AI code, or choosing tools. Focuses on tool selection, effective prompting, and iteration workflows for non-technical founders.

Perform peak calling for ChIP-seq or ATAC-seq data using MACS3, with intelligent parameter detection from user feedback. Use it when you want to call peaks for ChIP-seq data or ATAC-seq data.

Prioritize tasks and issues to determine what to work on and in what order. Use after identification, when planning work, or when unsure what to do next. This is the third system in the 5-system framework.

**Core Principle:** Understand the ripple effects. See how changes in one part affect the whole system.

This skill performs standardized quality control (QC) on Hi-C contact matrices stored in .mcool or .cool format. It computes coverage and cis/trans ratios, distance-dependent contact decay (P(s) curves), coverage uniformity, and replicate correlation at a chosen resolution using cooler and cooltools. Use it to assess whether Hi-C data are of sufficient quality for downstream analyses such as TAD calling, loop detection, and compartment analysis.

ALWAYS use this skill when user needs ANY API functionality (AI models, image generation, video, audio, text processing, etc.). Automatically search 302.AI's 1400+ APIs and generate integration code. Use proactively whenever APIs or AI capabilities are mentioned.

**Core Principle:** Think deeply, reason thoroughly, understand completely. Quality thinking for any situation.

This skill detects hierarchical (nested) TAD structures from Hi-C contact maps (in .cool or mcool format) using OnTAD, starting from multi-resolution .mcool files. It extracts a user-specified chromosome and resolution, converts the data to a dense matrix, runs OnTAD, and organizes TAD calls and logs for downstream 3D genome analysis.

Apply 37signals/DHH Rails conventions when writing Ruby on Rails code. Use when building Rails applications, reviewing Rails code, or making architectural decisions. Covers various aspects of Rails application architecture, design and dependencies.

Build a specification-first Digital FTE that orchestrates accumulated intelligence from Lessons 1-7. Learn to compose execution skills into production-ready agents, validate against specifications, and position for monetization.

Create a skill that orchestrates the write-execute-analyze loop to autonomously process data. Learn to implement error recovery, iterate toward robust solutions, and test your skill across diverse input scenarios. This is where specification-driven development meets real problem-solving.

You are an expert in 3D bin packing and three-dimensional space optimization. Your goal is to help pack 3D boxes and items into containers, trucks, or bins while maximizing space utilization, minimizi

Expert in building 3D experiences for the web - Three.js, React Three Fiber, Spline, WebGL, and interactive 3D scenes. Covers product configurators, 3D portfolios, immersive websites, and bringing depth to web experiences. Use when: 3D website, three.js, WebGL, react three fiber, 3D experience.

Performs ATAC-specific biological validation. It calculates metrics unique to chromatin accessibility assays, such as TSS enrichment scores and fragment size distributions (nucleosome banding patterns). Use this skill when you have filtered BAM file and have called peak for the file. Do NOT use this skill for ChIP-seq data or general alignment statistics.

Execute tasks with velocity and quality. Use when ready to implement after clarity and prioritization are complete. This is the fourth system in the 5-system framework.

Protect your SaaS app from common vulnerabilities. Use when building auth, handling user data, or deploying features. Covers authentication, data protection, API security, and OWASP Top 10 for non-technical founders using AI tools.

Coordinator workflow for orchestrating dockeragents through fix-review-iterate-present loop. Use when delegating any task that produces code changes. Ensures agents achieve 10/10 quality before presenting to human.

**Core Principle:** Know the path before walking. Have clear steps, know what success looks like, and be ready for what could go wrong.

Create your agent-tdd skill in one prompt, then learn to improve it throughout the chapter

Validate your agent-evals skill by testing it on a completely different agent. A skill proves its worth when it transfers beyond the context where you learned it.

World-class #1 expert 4PL and supply chain director specializing in AI-powered logistics optimization, digital transformation, warehouse automation, transportation management systems (TMS), inventory optimization algorithms, 3PL/4PL strategic partnerships, supply chain analytics, and global logistics operations. Use for any supply chain strategy, warehouse operations, route optimization, demand forecasting, or logistics technology decisions.

Brainstorms creative domain names for projects and checks availability across common TLDs (.com, .ai, .dev, .io, .app). Saves hours of manual searching. Use when starting a new project and need a domain name, or when rebranding existing projects.

Optimize your SaaS app across four dimensions - Speed (page load, API response), Code (unused files, dead code), Database (orphaned data, schema hygiene), and Dependencies (package bloat, bundle size). Use when app feels slow, codebase feels bloated, or after significant development work accumulates. Each path follows AUDIT → CLEAN → PREVENT workflow.