专注于 Python 后端开发，涵盖 FastAPI、异步编程和性能优化。

深度集成 Gitee MCP，实现 Issue 管理、PR 自动化提交、代码审查和版本发布的全流程自动化。

Git 版本控制与协作专家，涵盖 GitHub/Gitee 平台操作、Conventional Commits 规范及 PR/MR 最佳实践。

Transforms conversations and discussions into structured documentation pages in Notion. Captures insights, decisions, and knowledge from chat context, formats appropriately, and saves to wikis or databases with proper organization and linking for easy discovery.

专注于应用安全、认证授权与合规性。

专注于内容创作（文案、运营稿件）、运营数据分析、以及营销活动策划与设置。帮助项目实现从“可用”到“好用”及“增长”的闭环。

Perform comprehensive **preliminary alignment-level quality control** for ChIP-seq and ATAC-seq BAM files using **samtools**, **Picard**, and **MultiQC**.

Establish clarity before starting work. Use when beginning any significant task, when input is vague or stream-of-consciousness, or when requirements seem unclear. Handles messy voice input efficiently. This is the first system in the 5-system framework.

Determine the type of project and summarize the tech stack. Your summary should include:

A personal knowledge base for **building understanding that compounds over time**. Not a note dump - a structured system for capturing knowledge you can actually retrieve and use.

Turn ideas into clear, buildable specs for AI tools or stakeholder review. Use when starting features, planning projects, or when AI keeps building the wrong thing. Creates Quick Feature Specs (10-15 min) for immediate AI builds or Full Project Scopes (1-2 hours) for budget planning and contractor estimates.

This skill is used to perform genomic feature annotation and visualization for any file containing genomic region information using Homer (Hypergeometric Optimization of Motif EnRichment). It annotates regions such as promoters, exons, introns, intergenic regions, and TSS proximity, and generates visual summaries of feature distributions. ChIPseeker mode is also supported according to requirements.

Strategic amplification mode that reveals blind spots, untapped opportunities, and hidden leverage points in any business strategy, entrepreneurship idea, or creative content project. Cuts through noise to show what others miss.

Perform GO and KEGG functional enrichment using HOMER from genomic regions (BED/narrowPeak/broadPeak) or gene lists, and produce R-based barplot/dotplot visualizations. Use this skill when you want to perform GO and KEGG functional enrichment using HOMER from genomic regions or just want to link genomic region to genes.

The Twelve-Factor App methodology for building scalable, maintainable cloud-native applications. Use when designing backend services, APIs, microservices, or any software-as-a-service application. Triggers on deployment patterns, configuration management, process architecture, logging, and infrastructure decisions.

This skill identifies novel transcription factor binding motifs in the promoter regions of genes, or directly from genomic regions of interest such as ChIP-seq peaks, ATAC-seq accessible sites, or differentially acessible regions. It employs HOMER (Hypergeometric Optimization of Motif Enrichment) to detect both known and previously uncharacterized sequence motifs enriched within the supplied genomic intervals. Use the skill when you need to uncover sequence motifs enriched or want to know which TFs might regulate the target regions.

This skill should be used when users need to perform known motif enrichment analysis on ChIP-seq, ATAC-seq, or other genomic peak files using HOMER (Hypergeometric Optimization of Motif EnRichment). It identifies enrichment of known transcription factor binding motifs from established databases in genomic regions.

This skill identifies the locations of known transcription factor (TF) binding motifs within genomic regions such as ChIP-seq or ATAC-seq peaks. It utilizes HOMER to search for specific sequence motifs defined by position-specific scoring matrices (PSSMs) from known motif databases. Use this skill when you need to detect the presence and precise genomic coordinates of known TF binding motifs within experimentally defined regions such as ChIP-seq or ATAC-seq peaks.

This skill should be used when users need to infer chromatin states from histone modification ChIP-seq data using chromHMM. It provides workflows for chromatin state segmentation, model training, state annotation.

Automatically detect and normalize Hi-C data. Only .cool or .mcool file is supported. All .mcool files are then checked for existing normalization (supports bins/weight only) and balanced if none of the normalizations exist.

This skill performs PCA-based A/B compartments calling on Hi-C .mcool datasets using pre-defined MCP tools from the cooler-tools, cooltools-tools, and plot-hic-tools servers.

Master index for Odoo 18 guides. This file provides a quick reference to find the appropriate detailed guide for each topic. Use this as an index to locate specific guides when working with Odoo 18 code.

This skill should be used when users need to identify topologically associating domains (TADs) from Hi-C data in .mcools (or .cool) files or when users want to visualize the TAD in target genome loci. It provides workflows for TAD calling and visualization.

Master index for Odoo 19 guides. This file provides a quick reference to find the appropriate detailed guide for each topic. Use this as an index to locate specific guides when working with Odoo 19 code.

This skill performs chromatin loop detection from Hi-C .mcool files using cooltools.

You are an expert in one-dimensional cutting stock problems and linear cutting optimization. Your goal is to help minimize material waste and costs when cutting standard-length stock materials (pipes,

Guide for adding new blockchain chains to OneKey. Use when implementing new chain support, adding blockchain protocols, or understanding chain architecture. Triggers on chain, blockchain, protocol, network, coin, token, add chain, new chain.

Adds new WebSocket event subscriptions to OneKey. Use when implementing new socket events, handling server push messages, or adding real-time data subscriptions. Socket, WebSocket, event, subscription, push, real-time.

Create test versions to verify app auto-update functionality. Use when testing update flows, version migration, or validating app upgrade mechanisms. Automates version number and build number configuration for testing the auto-update system. Triggers on auto update, app upgrade, update testing, upgrade flow, version migration, test build, 9XXX version.

OneKey monorepo architecture and code organization. Use when understanding project structure, package relationships, import rules, or component organization. Triggers on architecture, structure, packages, imports, hierarchy, dependencies, monorepo, organization.

Code quality standards for OneKey. Use when fixing lint warnings, running pre-commit tasks, handling unused variables, writing comments, or ensuring code quality. All comments must be in English. Triggers on lint, linting, eslint, oxlint, tsc, type check, unused variable, comment, documentation, spellcheck, code quality, pre-commit, yarn lint.

Coding patterns and best practices for OneKey development. Use when writing React components, handling promises, error handling, or following code conventions. Triggers on react, component, hooks, promise, async, await, error, pattern, convention, typescript.

Cross-platform development patterns for OneKey. Use when writing platform-specific code, handling platform differences, or working with native/web/desktop/extension platforms. Triggers on platform, native, web, desktop, extension, iOS, Android, Electron, platformEnv, .native.ts, .web.ts, .desktop.ts, .ext.ts, cross-platform, multi-platform.

Date and time formatting for OneKey applications. Use when displaying dates, timestamps, or formatting time in UI components. Always use OneKey utilities instead of native JS date methods. Triggers on date, time, timestamp, formatDate, formatTime, toLocaleDateString, toLocaleString, dateUtils, locale, format, display date, show time, datetime, calendar.

Interactive guide for integrating new DeFi modules or protocols into OneKey. Use when adding new DeFi features like staking protocols, lending markets, or entirely new DeFi modules. Triggers on DeFi, protocol, integration, Earn, Borrow, staking, lending, supply, borrow, withdraw, repay, claim, new module, Pendle, Aave, Compound.

Development commands for OneKey monorepo. Use when running dev servers, building apps, linting, testing, or troubleshooting build issues. Triggers on yarn, dev, build, lint, test, desktop, mobile, web, extension, ios, android, compile, bundle.

Error handling patterns and best practices for OneKey. Use when implementing try/catch blocks, handling async errors, showing error messages, or managing error states in UI. Triggers on error, try, catch, exception, throw, fail, failure, error handling, error boundary, useAsyncCall, toast, fallback, error state.

Feature development guides for OneKey. Use when adding new chains, socket events, notifications, pages, or routes. Covers blockchain integration, WebSocket subscriptions, push notifications, and navigation patterns.

Git workflow and conventions for OneKey development. Use when creating branches, committing code, or creating PRs. Triggers on git, branch, commit, PR, pull request, merge, workflow.

Internationalization and translation management for OneKey. Use when adding translations, displaying text, handling locales, or managing translation keys. NEVER modify auto-generated translation files. Triggers on i18n, translation, locale, formatMessage, useIntl, ETranslations, text, string, hardcode, intl, translate, language, localization, internationalization.

Creates a new Claude Code Skill following best practices. Use when the user wants to create a new skill, add a skill, or asks about writing skills for Claude Code. Fetches latest documentation before generating skill content. New skill. Create a skill.

Patches native modules (expo-image, react-native, etc.) to fix native crashes or bugs.

Performance optimization guidelines for OneKey React/React Native applications. Use when optimizing app performance, fixing UI freezes/lag, reducing re-renders, handling concurrent operations, or analyzing performance bottlenecks. Triggers on performance, optimization, optimize, slow, lag, freeze, hang, jank, stutter, memory, leak, concurrent, batching, batch, memoization, memo, bridge, windowSize, contentVisibility, FlashList, re-render, fps, tti, bundle.

Documents minimum SDK/OS version requirements for all OneKey platforms. Use when checking platform compatibility, understanding deployment targets, verifying version requirements, or when user asks if their device can run the project. Triggers on minimum version, SDK version, API level, deployment target, platform requirements, iOS version, Android version, Chrome version, Electron version, can I run, environment check, device compatibility, check environment.

Analyze and fix production errors from Sentry crash reports. Use when investigating AppHang, ANR, crashes, or production errors. Includes complete workflow from JSON analysis to bug fix implementation with evidence-based methodology. Triggers on sentry, crash, AppHang, ANR, error analysis, production error, bug analysis, crash report, freeze, hang, not responding, stacktrace, breadcrumbs, exception.

Sentry error tracking and monitoring for OneKey. Use when configuring Sentry, filtering errors, analyzing crash reports, or debugging production issues. Covers platform-specific setup (desktop/mobile/web/extension) and error filtering strategies.

Jotai state management patterns for OneKey. Use when working with atoms, global state, feature state, or context atoms. Triggers on jotai, atom, state, globalAtom, contextAtom, store, persistence, settings.

Use this skill when working with the 1Password CLI (`op` command) for secrets management, retrieving API keys, or injecting secrets into development environments.

Configures 1Password CLI with direnv for fast, secure credential loading. Activates for: 1Password + direnv setup, slow secrets (>2 sec), .env.op files, op:// references, AWS credentials via env vars, --reveal flag issues, repeated biometric prompts, creating 1Password items programmatically, op item get errors. Not for: 1Password GUI usage, SSH keys (use 1Password SSH agent).

1password-secrets